Ammonium Chloride → HCID 66883868、化合物

HRID 1631346ノート

反応式

HRID 1631346 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@@H:9]1[N:13]([C:14]2[CH:19]=[CH:18][N:17]3[N:20]=[CH:21][C:22]([C:23]([OH:25])=O)=[C:16]3[N:15]=2)[C:12]([CH3:27])([CH3:26])[CH2:11][CH2:10]1.[Cl-].[NH4+:29]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@@H:9]1[N:13]([C:14]2[CH:19]=[CH:18][N:17]3[N:20]=[CH:21][C:22]([C:23]([NH2:29])=[O:25])=[C:16]3[N:15]=2)[C:12]([CH3:27])([CH3:26])[CH2:11][CH2:10]1

参加物

3

反応物 2

HCID 25517Ammonium ChlorideHCID 66847784HCID 66847784、化合物

生成物 1

HCID 66883868HCID 66883868、化合物収率 33%

実験手順

Prepared by the method described in Example 1 using (R)-5-(5-(2,5-difluorophenyl)-2,2-dimethylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid and ammonium chloride. The crude material was purified by reverse phase HPLC (0-70% acetonitrile/water) to provide the title compound (8.5 mg, 33% yield). MS (apci) m/z=372.1 (M+H).

後処理

  1. customPrepared by the method
  2. customThe crude material was purified by reverse phase HPLC (0-70% acetonitrile/water)

出典と根拠

ORDレコード
ord-9e918560ed744a46b905a251584d80e5
出典データセット
uspto-grants-2014_07
特許番号
US08791123B2

反応ノート

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