Hydrochloric Acid → 1-(Trifluoromethyl)cyclopropanamine hydrochloride
反応式
[F:1][C:2]([F:15])([F:14])[C:3]1([NH:6]C(=O)OC(C)(C)C)[CH2:5][CH2:4]1.[ClH:16]>>[ClH:16].[F:1][C:2]([F:15])([F:14])[C:3]1([NH2:6])[CH2:5][CH2:4]1参加物
3
実験手順
A solution of tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate (0.3 g, 1.3 mmol) in HCl (4 N dioxane, 6.7 mL, 27 mmol) was stirred at ambient temperature overnight. The reaction was then concentrated to yield the crude product as white solid, which was used directly in the next step assuming quantitative yield.
後処理
- concentrationThe reaction was then concentrated
出典と根拠
- ORDレコード
- ord-4b2961abd96b4c80aa3a7da09cbbd5fc
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08791123B2
反応ノート
読み込み中…