tert-butyl N-[(1S,4R)-4-hydroxycycloheptyl]carbamate → (1S,4R)-4-aminocycloheptan-1-ol
反応式
[OH:1][C@@H:2]1[CH2:8][CH2:7][CH2:6][C@H:5]([NH:9]C(=O)OC(C)(C)C)[CH2:4][CH2:3]1>Cl.O1CCOCC1>[NH2:9][C@@H:5]1[CH2:6][CH2:7][CH2:8][C@H:2]([OH:1])[CH2:3][CH2:4]1参加物
4
実験手順
A sample of 23B (0.070 g, 0.31 mmol) was dissolved in 2 mL of 4M HCl in dioxane and stirred 1.5 h. The reaction was concentrated under reduced pressure to afford 23C.HCl (51 mg, quantitative yield) as a white solid. This material was used without characterization in the subsequent step.
後処理
- concentrationThe reaction was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-48f17da55f8149b284b04473bae9b1e7
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08791257B2
反応ノート
読み込み中…