化工社化工社 化学情報印刷レポート · 研究参考用
Methyl vinyl ketone → Spiro(4.5)dec-6-ene-8-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl vinyl ketone | HCID 6570 | — |
| 反応物 | Cyclopentanecarbaldehyde | HCID 70106 | — |
| 生成物 | Spiro(4.5)dec-6-ene-8-one | HCID 139772 | 54% |
反応手順
Piperidine enamine was prepared by a method analogous to that described in Organic Syntheses, Collective Volume 7, p 473, using 221.84 g of cyclopentane carbaldehyde instead of cyclooctane carbaldehyde. Through Michael addition of piperidine enamine to methyl vinyl ketone, cyclization by aldol condensation, dehydration, hydrolysis, and vacuum distillation for purification, there was obtained 173.4 g (yield 54%) of spiro[4.5]dec-6-en-8-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08791288B2 |
| 出典データセット | uspto-grants-2014_07 |
| ORD ID | ord-c5f62ab611364ee3909ce0b58766bf29 |
| 出典メモ | uspto-grants-2014_07 |