反応式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][NH:5][CH2:6]2.C(O[C:14]1[O:15][CH2:16][CH2:17][N:18]=1)C.C1C2C(=CC=CC=2)C=CC=1S(O)(=O)=O>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][N:5]([C:14]1[O:15][CH2:16][CH2:17][N:18]=1)[CH2:6]2参加物
5
反応条件
- 温度
- 100 °C
実験手順
A mixture of 4-fluoroisoindoline (400 mg), 2-ethoxy-2-oxazoline (400 mg), and β-naphthylsulfonic acid (30 mg) in 50 ml of toluene was stirred at 100° C. for 1 hour. The solvent as removed under reduced pressure, and the residue chromatographed on silica gel, eluting with 1-4% methanol in ethyl acetate, to give 4-fluoro-2-(oxazolin-2-yl)isoindoline, a compound of Formula (IB), m.p. 125°-129° C.
後処理
- customThe solvent as removed under reduced pressure
- customthe residue chromatographed on silica gel
- washeluting with 1-4% methanol in ethyl acetate
出典と根拠
- ORDレコード
- ord-0aed4da618f94372b6ebcb5dce352131
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05726197
関連ノート
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