2-Amino-carbethoxycarbonylmethyl-quinoxalinium bromide → Ethyl imidazo[1,2-a]quinoxaline-2-carboxylate
反応式
[Br-].[NH2:2][C:3]1[CH:12]=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N+:4]=1[CH2:13][C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=O>C(O)C>[CH:13]1[N:4]2[C:5]3[C:10]([N:11]=[CH:12][C:3]2=[N:2][C:14]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:9][CH:8]=[CH:7][CH:6]=3参加物
3
実験手順
A suspension of 0.4 g of the product of Step A in 15 ml of ethanol was refluxed for 2 hours and the resulting clear orange solution was concentrated to half its volume. The mixture was filtered to obtain 0.25 g of ethyl imidazo-[1,2-a]-quinoxaline-2-carboxylate as a pale yellow solid which were crystallized from an ether-methanol mixture to obtain the product in the form of soft-white needles melting at 184°-187° C. with decomposition.
後処理
- temperaturewas refluxed for 2 hours
- concentrationthe resulting clear orange solution was concentrated to half its volume