Triphenylphosphine → Methyl 3-acetylthio-7-oxo-4-thia-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate

HRID 1632253

反応式

HRID 1632253 の反応式
[C:1]([S:4][C:5]1[S:12]S[CH:10]2[N:7]([C:8](=[O:13])[CH2:9]2)[C:6]=1[C:14]([O:16][CH3:17])=[O:15])(=[O:3])[CH3:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>[2H]C(Cl)(Cl)Cl>[C:1]([S:4][C:5]1[S:12][CH:10]2[N:7]([C:8](=[O:13])[CH2:9]2)[C:6]=1[C:14]([O:16][CH3:17])=[O:15])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 11776TriphenylphosphineHCID 20275793Methyl 3-acetylthio-8-oxo-4,5-dithia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylate

生成物 1

HCID 20275792Methyl 3-acetylthio-7-oxo-4-thia-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate収率 61.5%

試薬・触媒・溶媒 1

HCID 71583Chloroform-D溶媒

実験手順

0.064 g of methyl 3-acetylthio-8-oxo-4,5-dithia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylate was dissolved in 1 ml of deuterochloroform and 0.063 g of triphenylphosphine added. TLC and NMR analysis indicated complete conversion of starting material to product. The crude product was chromatographed on silica gel using ethyl acetate/hexane as eluant to give 0.035 g (61%) of purified product.

後処理

  1. customThe crude product was chromatographed on silica gel

出典と根拠

ORDレコード
ord-ddeba94f0d8b4b748dcb5ba540beb049
出典データセット
uspto-grants-1984_10
特許番号
US04474793

関連ノート

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