Ethylenediamine → N-[2-(amino)ethyl]-2-(3-hydroxy-2oxo-1-pyrrolidinyl)acetamide
反応式
[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([O:10]CC)=O)[C:3]1=[O:13].[CH2:14]([NH2:17])[CH2:15][NH2:16]>>[NH2:16][CH2:15][CH2:14][NH:17][C:8](=[O:10])[CH2:7][N:4]1[CH2:5][CH2:6][CH:2]([OH:1])[C:3]1=[O:13]参加物
3
実験手順
A mixture of 3.5 g of ethyl (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetate and 11.2 g of 1,2-ethylenediamine is left to stand at room temperature for 20 hours. The excess 1,2-ethylenediamine is evaporated in vacuo. The residue is dissolved in 40 ml of hot acetonitrile and stirred at room temperature for 2 hours and then in an ice-bath for 1 hour. By filtration there is isolated N-[2-(amino)ethyl]-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide of melting point 110°-112°.
後処理
- waitis left
- customThe excess 1,2-ethylenediamine is evaporated in vacuo
- dissolutionThe residue is dissolved in 40 ml of hot acetonitrile
- waitin an ice-bath for 1 hour
- filtrationBy filtration
出典と根拠
- ORDレコード
- ord-88ff558987254dfca9a08a3c87c2fbff
- 出典データセット
- uspto-grants-1984_10
- 特許番号
- US04476308
反応ノート
読み込み中…