1-Pyrrolidineacetamide, 3-hydroxy-2-oxo-, (+-)- → (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)propionamide

HRID 1632562ノート

反応式

HRID 1632562 の反応式
[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([NH2:10])=[O:9])[C:3]1=[O:11].O[CH:13]1CCN(C(C)C(OCC)=O)C1=O>>[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([CH:7]([CH3:13])[C:8]([NH2:10])=[O:9])[C:3]1=[O:11]

参加物

3

反応物 2

HCID 30698541-Pyrrolidineacetamide, 3-hydroxy-2-oxo-, (+-)-HCID 76485496ethyl (R/S)-2-(3-hydroxy-2-oxo-1-pyrroldinyl)propionate

生成物 1

HCID 54458868(R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)propionamide

実験手順

According to the process described in paragraph (b) of Example 1, from ethyl (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)propionate there is obtained, after chromatographic filtration on silica gel (granular size 0.2-0.5 mm), elution with acetonitrile/ethanol (1:1) and crystallization from acetonitrile, (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)propionamide of melting point 139°-141°.

後処理

  1. customthere is obtained
  2. filtrationafter chromatographic filtration
  3. washon silica gel (granular size 0.2-0.5 mm), elution
  4. customwith acetonitrile/ethanol (1:1) and crystallization from acetonitrile, (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)propionamide of melting point 139°-141°

出典と根拠

ORDレコード
ord-662c44b38db042d5a82f56d7f4bf9fe2
出典データセット
uspto-grants-1984_10
特許番号
US04476308

反応ノート

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