化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 3,4,5-Trihydroxybenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Gallic Acid | HCID 370 | — |
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Phosphorus trichloride | HCID 24387 | — |
| 反応物 | Benzoic acid, 3,4,5-tris(acetyloxy)- | HCID 95088 | — |
| 反応物 | 3,4,5-Triacetoxybenzoyl chloride | HCID 155506 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 3,4,5-Trihydroxybenzamide | HCID 69256 | — |
反応手順
Namely, gallic acid is converted into 3,4,5-triacetoxybenzoic acid by reacting with acetic anhydride or acetic acid chloride in the presence of a base such as NaOH (J. Chem. Soc., 2495 (1931)), Na2CO3, pyridine or so on and, further, converted into the corresponding acid chloride by reacting with thionyl chloride or phosphorus trichloride. The thus-obtained 3,4,5-triacetoxybenzoic acid chloride was made to react with an appropriate amine in the presence of a base such as pyridine, triethylamine or the like. Thereafter, the reaction product is treated with sodium acetate, sodium hydroxide or hydrochloric acid in methanol or ethanol to produce an intended gallic acid amide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04476219 |
| 出典データセット | uspto-grants-1984_10 |
| ORD ID | ord-cdde5cb78ea24ee3b3a1e264077d2e68 |
| 出典メモ | uspto-grants-1984_10 |