Ammonium Hydroxide → S-o-nitrophenyl-L-cysteine

HRID 1632768ノート

反応式

HRID 1632768 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10][CH2:11][C@@H:12]([C:17]([OH:19])=[O:18])[NH:13]C(=O)C)([O-:3])=[O:2].[OH-].[NH4+]>S(=O)(=O)(O)O.O>[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10][CH2:11][C@@H:12]([C:17]([OH:19])=[O:18])[NH2:13])([O-:3])=[O:2]

参加物

5

反応物 2

HCID 14923Ammonium HydroxideHCID 185068L-Cysteine, N-acetyl-S-(2-nitrophenyl)-

生成物 1

HCID 124713S-o-nitrophenyl-L-cysteine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1118Sulfuric Acid溶媒

実験手順

A solution of 71 g of S-(o-nitrophenyl)-N-acetyl-L-cysteine in 300 ml of 18M sulfuric acid and 1200 ml of water is heated to reflux for 30 min. The solution is cooled in ice and treated with 700 ml of concentrated ammonium hydroxide. The resulting solid is recrystallized from boiling water to afford S-(o-nitrophenyl)-L-cysteine; m.p. 168°-171° C.; [α]D =+67.3° (c=1.1, 1N hydrochloric acid).

後処理

  1. temperatureto reflux for 30 min
  2. temperatureThe solution is cooled in ice
  3. customThe resulting solid is recrystallized

出典と根拠

ORDレコード
ord-aec0a29497ac4592b79b9a5c838332be
出典データセット
uspto-grants-1984_10
特許番号
US04477464

反応ノート

読み込み中…