Ammonia → 6-(Aminomethyl)pyrimidine-2,4(1H,3H)-dione

HRID 1632979

反応式

HRID 1632979 の反応式
Cl[CH2:2][C:3]1[NH:8][C:7](=[O:9])[NH:6][C:5](=[O:10])[CH:4]=1.[NH3:11]>C(OCC)(=O)C>[NH2:11][CH2:2][C:3]1[NH:8][C:7](=[O:9])[NH:6][C:5](=[O:10])[CH:4]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 732736-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione

生成物 1

HCID 3129536-(Aminomethyl)pyrimidine-2,4(1H,3H)-dione

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 100 g (0.623 mole) of 6-chloromethylpyrimidine-2,4-dione and 200 ml of anhydrous ammonia was allowed to react overnight in a sealed bomb at about 20° C. The solid residue was slurried in ethyl acetate, and was then separated by filtration and washed sequentially with water and methanol to provide 6-aminomethylpyrimidine-2,4-dione, m.p. 295°-297° C.

後処理

  1. customto react overnight in a sealed bomb at about 20° C
  2. customwas then separated by filtration
  3. washwashed sequentially with water and methanol

出典と根拠

ORDレコード
ord-5adf28619ccd4cc8b37519390f821a69
出典データセット
uspto-grants-1984_10
特許番号
US04478835

関連ノート

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