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Methyl 4-(2-aminoethyl)benzoate → N-(2-[4-Carbomethoxyphenyl]-1,1-dimethylethyl)-2-hydroxy-2-(4-benzyloxy-3-hydroxymethylphenyl)-ethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 4-(2-aminoethyl)benzoate | HCID 11183521 | — |
| 反応物 | 4-Benzyloxy-3-hydroxymethylphenylglyoxal | HCID 20134166 | — |
| 反応物 | Methyl 4-(2-amino-2-methylpropyl)benzoate | HCID 20134200 | — |
| 生成物 | N-(2-[4-Carbomethoxyphenyl]-1,1-dimethylethyl)-2-hydroxy-2-(4-benzyloxy-3-hydroxymethylphenyl)-ethanamine | HCID 20134220 | — |
反応手順
The title compound was prepared by the process of Example 25, replacing phenyl glyoxal by 4-benzyloxy-3-hydroxymethylphenyl glyoxal and 2-(4-carbomethoxyphenyl) ethanamine by 2-(4-carbomethoxyphenyl)-1,1-dimethylethanamine. τ (d6DMSO) 9.06 (6H, s), 7.10-7.60 (5H, m), 6.20 (3H, s), 5.39 (2H, s), 5.00 (1H, m), 4.88 (2H, s), 3.04 (2H, d, J=8 Hz), 2.40-3.00 (10H, m), 2.12 (2H, d, J=8 Hz).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04478849 |
| 出典データセット | uspto-grants-1984_10 |
| ORD ID | ord-2351659d1b70450cbe7f01d8e2c4a901 |
| 出典メモ | uspto-grants-1984_10 |