Aniline → Methyl 6-(phenylamino)hexanoate

HRID 1633150ノート

反応式

HRID 1633150 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15].O.O.O.C([O-])(=O)C.[Na+]>C(O)C>[CH3:17][O:16][C:14]([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:15]

参加物

5

反応物 3

HCID 6115AnilineHCID 4170292Methyl 6-BromohexanoateHCID 23665404Sodium Acetate Trihydrate

生成物 1

HCID 20441676Methyl 6-(phenylamino)hexanoate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Aniline (2.79 g, 2.73 ml), 6.27 g of methyl 6-bromohexanoate and 12.24 g (0.09 mole) of sodium acetate trihydrate are heated at 80°-100° overnight in 15 ml of absolute ethanol. After cooling, the mixture is poured into 75 ml of ice-water and extracted with ether. The organic extract is washed with water, dried over magnesium sulfate and evaporated in vacuo to give N-(5-methoxycarbonylpentyl)aniline.

後処理

  1. temperatureAfter cooling
  2. extractionextracted with ether
  3. extractionThe organic extract
  4. washis washed with water
  5. dry with materialdried over magnesium sulfate
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-3ac78de5eb604d259375d050c0e78e7f
出典データセット
uspto-grants-1984_10
特許番号
US04478842

反応ノート

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