Hydrochloric Acid → N-nitroso-N-(5-methoxycarbonylpentyl)-aniline

HRID 1633151ノート

反応式

HRID 1633151 の反応式
[N:1]([O-:3])=O.[Na+].[CH3:5][O:6][C:7]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:8].Cl>O>[N:1]([N:14]([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C:7]([O:6][CH3:5])=[O:8])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 20441676Methyl 6-(phenylamino)hexanoateHCID 23668193Sodium Nitrite

生成物 1

HCID 13362122N-nitroso-N-(5-methoxycarbonylpentyl)-aniline

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 1.4 g of sodium nitrite in 5 ml of water is added dropwise at 0°-10° to a mixture of 4.42 g of N-(5-methoxycarbonylpentyl)-aniline, 2.9 ml of concentrated hydrochloric acid, and ice as needed to maintain the desired temperature. The mixture is then allowed to stir at ambient temperature for 1 hour and is then extracted with ether. The extract is washed with water, dried over magnesium sulfate, and evaporated in vacuo to give N-nitroso-N-(5-methoxycarbonylpentyl)-aniline as an oil.

後処理

  1. temperatureto maintain the desired temperature
  2. extractionis then extracted with ether
  3. washThe extract is washed with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-13e73071e92d43899593294fa55b015d
出典データセット
uspto-grants-1984_10
特許番号
US04478842

反応ノート

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