1-(6-Amino-9H-purin-9-yl)-3-[N-tert-butoxycarbonyl-beta-(4-fluorophenyl)-D,L-alanylamino]-1,3-dideoxy-beta-D-ribofuranuronic acid → 3-[2-Amino-3-(4-fluorophenyl)propanoylamino]-5-(6-aminopurin-9-yl)-4-hydroxyoxolane-2-carboxylic acid
反応式
[NH2:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@@H:11]1[O:16][C@H:15]([C:17]([OH:19])=[O:18])[C@@H:14]([NH:20][C:21](=[O:39])[CH:22]([CH2:31][C:32]2[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=2)[NH:23]C(OC(C)(C)C)=O)[C@H:12]1[OH:13]>C(O)=O>[NH2:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@@H:11]1[O:16][C@H:15]([C:17]([OH:19])=[O:18])[C@@H:14]([NH:20][C:21](=[O:39])[CH:22]([CH2:31][C:32]2[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=2)[NH2:23])[C@H:12]1[OH:13]参加物
3
反応物 1
生成物 1
試薬・触媒・溶媒 1
実験手順
1-(6-Amino-9H-purin-9-yl)-3-[β-(4-fluorophenyl)-D,L-alanylamino]-1,3-dideoxy-β-D-ribofuranuronic acid (173 mg) was prepared by reacting 1-(6-amino-9H-purin-9-yl)-3-[N-tert-butoxycarbonyl-β-(4-fluorophenyl)-D,L-alanylamino]-1,3-dideoxy-β-D-ribofuranuronic acid (320 mg) prepared in Example 27 and formic acid (5 ml) according to a similar manner to that of Example 45, mp. 120°-130° C. (dec.).