Hydrochloric Acid → 239113-23-6

HRID 1633556ノート

反応式

HRID 1633556 の反応式
[Cl:1][C:2]1[C:3]([CH:12]([N:20]=C(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.Cl>C(OCC)C>[ClH:1].[Cl:1][C:2]1[C:3]([CH:12]([NH2:20])[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22629930HCID 22629930、化合物

生成物 1

HCID 69351932239113-23-6

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of the product from stage b) (1.29 g) in diethyl ether (5 ml) was added 1 M hydrochloric acid (10 ml) at room temperature and the solution was stirred at room temperature for 2 hours. The mixture was filtered to give a solid, which was washed with water (15 ml) then ether (15 ml). Drying in vacuo gave the title product. Water was removed from the aqueous phase by azeotropic distillation with toluene (×3), to give further quantities of the title product.

後処理

  1. filtrationThe mixture was filtered
  2. customto give a solid, which
  3. washwas washed with water (15 ml)
  4. customDrying in vacuo

出典と根拠

ORDレコード
ord-8253864d320440f4997bf8ce9385ebf1
出典データセット
uspto-grants-2003_01
特許番号
US06503933B1

反応ノート

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