Benzene, 1-fluoro-4-(trifluoromethyl)- → Allyl-methyl-{5-[1-(4-trifluoromethyl-phenyl)-1H-indol-5-yl]-pentyl}-amine

HRID 1633650

反応式

HRID 1633650 の反応式
[CH2:1]([N:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][CH:15]=[CH:14]2)[CH3:5])[CH:2]=[CH2:3].F[C:21]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=1>>[CH2:1]([N:4]([CH3:5])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[N:16]([C:21]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=1)[CH:15]=[CH:14]2)[CH:2]=[CH2:3]

参加物

3

反応物 2

HCID 67873Benzene, 1-fluoro-4-(trifluoromethyl)-HCID 18679431Allyl-[5-(1H-indol-5-yl)-pentyl]-methyl-amine

生成物 1

HCID 18679482Allyl-methyl-{5-[1-(4-trifluoromethyl-phenyl)-1H-indol-5-yl]-pentyl}-amine

実験手順

In analogy to example 4.6, Allyl-[5-(1H-indol-5-yl)-pentyl]-methyl-amine and 1-fluoro-4-trifluoromethyl-benzene were converted to yield Allyl-methyl-{5-[1-(4-trifluoromethyl-phenyl)-1H-indol-5-yl]-pentyl}-amine as light brown oil, MS: 401 (MH+).

出典と根拠

ORDレコード
ord-72e97fe767814c15863365ccff6964d9
出典データセット
uspto-grants-2003_01
特許番号
US06503907B2

関連ノート

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