Potassium Carbonate → HCID 18679523、化合物

HRID 1633664ノート

反応式

HRID 1633664 の反応式
C[Si]([C:5]#[C:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[C:21]3[C:16](=[CH:17][C:18]([C:22]#[C:23][CH2:24][CH2:25][CH2:26][OH:27])=[CH:19][CH:20]=3)[CH:15]=[CH:14]2)=[CH:9][CH:8]=1)(C)C.C([O-])([O-])=O.[K+].[K+]>CO>[C:6]([C:7]1[CH:12]=[CH:11][C:10]([N:13]2[C:21]3[C:16](=[CH:17][C:18]([C:22]#[C:23][CH2:24][CH2:25][CH2:26][OH:27])=[CH:19][CH:20]=3)[CH:15]=[CH:14]2)=[CH:9][CH:8]=1)#[CH:5]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 186794765-[1-(4-Trimethylsilanylethynyl-phenyl)-1H-indol-5-yl]-pent-4-yn-1-ol

生成物 1

HCID 18679523HCID 18679523、化合物収率 87.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

970 mg (2.6 mmol) 5-[1-(4-Trimethylsilanylethynyl-phenyl)-1H-indol-5-yl]-pent-4-yn-1-ol in 10 ml MeOH were treated with 41.4 mg (3 mmol) K2CO3. The solution was concentrated, the residue dissolved in ether and 0.5M HCl and the organic phase was washed with water and dried over Na2SO4. Column chromatography on silica gel with ether yielded 680 mg (87%) 5-[1-(4-Ethynyl-phenyl)-1H-indol-5-yl]-pent-4-yn-1-ol as orange oil, MS: 299 (M).

後処理

  1. concentrationThe solution was concentrated
  2. dissolutionthe residue dissolved in ether
  3. wash0.5M HCl and the organic phase was washed with water
  4. dry with materialdried over Na2SO4

出典と根拠

ORDレコード
ord-d865e9172b944a3db7eca46594e8f725
出典データセット
uspto-grants-2003_01
特許番号
US06503907B2

反応ノート

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