Acetic Acid → 2-[1-(4-Chlorophenyl)ethyl]-4-isopropyl-4-methyl-1,3-oxazol-5-one

HRID 1633802ノート

反応式

HRID 1633802 の反応式
C(O)(=[O:3])C.S(=O)(=O)(O)O.O.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH:18]([CH3:29])[C:19]([NH:21][C:22]([C:27]#N)([CH3:26])[CH:23]([CH3:25])[CH3:24])=[O:20])=[CH:14][CH:13]=1>C(OCC)(=O)C>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH:18]([C:19]2[O:20][C:26](=[O:3])[C:22]([CH:23]([CH3:25])[CH3:24])([CH3:27])[N:21]=2)[CH3:29])=[CH:14][CH:13]=1

参加物

6

反応物 4

HCID 176Acetic AcidHCID 962Water2 回HCID 1118Sulfuric AcidHCID 186801792-(4-chlorophenyl)-N-(1-cyano-1,2-dimethylpropyl)propanamide

生成物 1

HCID 113120132-[1-(4-Chlorophenyl)ethyl]-4-isopropyl-4-methyl-1,3-oxazol-5-one収率 100%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
60 °C

実験手順

40 ml of glacial acetic acid, 1.96 g (0.019 mole) of concentrated sulfuric acid and 0.36 g (0.02 mole) of water were added to 5.56 g (0.02 mole) of 2-(4-chlorophenyl)-N-(1-cyano-1,2-dimethylpropyl)propanamide. The mixture was stirred at 60° C. for 2 hours to give rise to a reaction. After the completion of the reaction, the reaction mixture was cooled. Thereto were added 400 ml of water and 400 ml of ethyl acetate for layer separation. The organic layer was washed with a saturated aqueous sodium bicarbonate solution and a saturated aqueous sodium chloride solution, and concentrated to obtain 5.58 g of 2-[1-(4-chlorophenyl)ethyl]-4-isopropyl-4-methyl-1,3-oxazol-5-one (yield=100%).

後処理

  1. customto give rise
  2. customto a reaction
  3. customAfter the completion of the reaction
  4. temperaturethe reaction mixture was cooled
  5. customfor layer separation
  6. washThe organic layer was washed with a saturated aqueous sodium bicarbonate solution
  7. concentrationa saturated aqueous sodium chloride solution, and concentrated

出典と根拠

ORDレコード
ord-ec339a86d8a94b1886f1c1ed8e8d1474
出典データセット
uspto-grants-2003_01
特許番号
US06504046B1

反応ノート

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