Potassium Hydroxide → 6-(Methoxycarbonyl)naphthalene-2-carboxylic acid

HRID 1633863

反応式

HRID 1633863 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([O:13][CH3:14])=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:15]([O:17]C)=[O:16].[OH-].[K+]>O1CCOCC1.CO>[CH3:14][O:13][C:11]([C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[CH:1]=[C:2]([C:15]([OH:17])=[O:16])[CH:3]=[CH:4]2)=[O:12]

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 61225Dimethyl-2,6-naphthalenedicarboxylate

生成物 1

HCID 33802176-(Methoxycarbonyl)naphthalene-2-carboxylic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

反応条件

温度
70 °C

実験手順

A solution of dimethyl 2,6-naphthalenedicarboxylate (39.6 g, 162 mmol) in dioxane (1.2 L) was heated to 70-80° C., slowly treated with a solution of KOH (9.1 g, 162 mmol) in methanol (162 mL), heated to 70° C., stirred for 30 minutes, cooled to room temperature, and filtered. The solid was washed sequentially with dioxane and diethyl ether, dissolved in water, adjusted to pH<7 with 1M HCl, and filtered. The solid was washed with water and dried to provide the desired product.

後処理

  1. temperaturecooled to room temperature
  2. filtrationfiltered
  3. washThe solid was washed sequentially with dioxane and diethyl ether
  4. dissolutiondissolved in water
  5. filtrationfiltered
  6. washThe solid was washed with water
  7. customdried

出典と根拠

ORDレコード
ord-0692141528424371891d9b7224ec0429
出典データセット
uspto-grants-2003_01
特許番号
US06504031B1

関連ノート

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