alpha-Chloro-m-nitrotoluene → 1-(Methanesulfonylmethyl)-3-nitrobenzene
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7]Cl)([O-:3])=[O:2].[CH3:12][S:13]([O-:15])=[O:14].[Na+]>CN(C=O)C>[CH3:12][S:13]([CH2:7][C:6]1[CH:9]=[CH:10][CH:11]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)(=[O:15])=[O:14]参加物
4
実験手順
m-Nitrobenzyl chloride (4.21 g, 24.5 mmol) was dissolved in DMF (40 mL) and added sodium methanesulfinate (3.00 g, 29.4 mmol) and the resulting mixture was stirred at room temperature for 16 hours. After evaporation of the solvent in vacuo the residue was partitioned between water (100 mL) and ethyl acetate (100 mL). The aqueous phase was extracted with ethyl acetate (100 mL) and the combined organic phases were dried (MgSO4) and evaporated in vacuo to afford 4.45 g (84%) 1-methylsulfonylmethyl-3-nitrobenzene.
後処理
- customAfter evaporation of the solvent in vacuo the residue
- customwas partitioned between water (100 mL) and ethyl acetate (100 mL)
- extractionThe aqueous phase was extracted with ethyl acetate (100 mL)
- dry with materialthe combined organic phases were dried (MgSO4)
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-252cde595219478eb372eacd67fc411e
- 出典データセット
- uspto-grants-2003_01
- 特許番号
- US06503949B1
反応ノート
読み込み中…