6-(3-Cyanopropyloxy)nicotinic acid, methyl ester → 6-(3-Cyanopropyloxy)nicotinic acid
反応式
[C:1]([CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=[O:12])=[CH:9][N:8]=1)#[N:2]>CO.O>[C:1]([CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:16]=[CH:15][C:10]([C:11]([OH:13])=[O:12])=[CH:9][N:8]=1)#[N:2]参加物
3
実験手順
6-(3-cyanopropyloxy)nicotinic acid, methyl ester (1.8 mmol) was dissolved in methanol/water (16 mL:4 mL) and treated with LiOH monohydrate (2.7 mmol). After stirring overnight, volatiles were removed and reaction neutralized with 1N sulfuric acid. The solid product was collected by filtration, washed with water and dried to give 6-(3-cyanopropyloxy)nicotinic acid (315 mg, 85%).
後処理
- customvolatiles were removed
- customreaction neutralized with 1N sulfuric acid
- filtrationThe solid product was collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-b2e80849fd214f5b823e02b009c219d4
- 出典データセット
- uspto-grants-2003_01
- 特許番号
- US06506747B1
反応ノート
読み込み中…