3-(2-Fluoro-5-(trifluoromethyl)benzyl)amino-2-phenylpiperidine dihydrochloride → (2S,3S)-2-Phenyl-3-(5-(1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl)-2-methoxybenzyl)aminopiperidine dihydrochloride
反応式
[ClH:1].Cl.[C:3]1([C@H:9]2[C@@H:14]([NH2:15])[CH2:13][CH2:12][CH2:11][NH:10]2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[F:16][C:17]([C:26]1[CH:27]=[CH:28][C:29]([O:34][CH3:35])=[C:30]([CH:33]=1)[CH:31]=O)([C:22]([F:25])([F:24])[F:23])[C:18]([F:21])([F:20])[F:19].Cl.Cl.FC1C=CC(C(F)(F)F)=CC=1CNC1CCCNC1C1C=CC=CC=1>>[ClH:1].[ClH:1].[C:3]1([C@H:9]2[C@@H:14]([NH:15][CH2:31][C:30]3[CH:33]=[C:26]([C:17]([F:16])([C:18]([F:19])([F:20])[F:21])[C:22]([F:23])([F:24])[F:25])[CH:27]=[CH:28][C:29]=3[O:34][CH3:35])[CH2:13][CH2:12][CH2:11][NH:10]2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1参加物
4
反応物 3
生成物 1
実験手順
This compound was prepared from Compound 1 and Compound 17 in the same manner of Compound 2.