Hydrochloric Acid → 1-Ethyl-2-hydroxymethyl-3-hydroxy-pyridin-4(1H)-one hydrochloride
反応式
[CH2:1]([N:3]1[CH:8]=[CH:7][C:6](=[O:9])[C:5]([O:10]CC2C=CC=CC=2)=[C:4]1[CH2:18][O:19]C)[CH3:2].[ClH:21]>>[ClH:21].[CH2:1]([N:3]1[CH:8]=[CH:7][C:6](=[O:9])[C:5]([OH:10])=[C:4]1[CH2:18][OH:19])[CH3:2]参加物
3
実験手順
2.0 g (7.33 mmol) 1-ethyl-2-methoxymethyl-3-benzyloxy-pyridin-4(1H)-one was dissolved in 50 ml of 4N hydrochloric acid and refluxed for 6 hours. Concentration to dryness in vacuo afforded the crude product. Recrystallisation from methanol/diethyl ether gave the pure title compound (1.1 g, 73%) as a white crystalline solid. m.p. 168-169° C.
後処理
- temperaturerefluxed for 6 hours
- concentrationConcentration to dryness in vacuo
- customafforded the crude product
- customRecrystallisation from methanol/diethyl ether
出典と根拠
- ORDレコード
- ord-7046537c68594570b87c28d6c63a70ac
- 出典データセット
- uspto-grants-2003_01
- 特許番号
- US06506911B2
反応ノート
読み込み中…