Aluminium lithium hydride → (1-Isopropylpiperidin-4-yl)methanamine

反応式

[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([NH2:12])=O)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[NH2:12][CH2:10][CH:7]1[CH2:8][CH2:9][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6]1

参加物

反応物 2

HCID 21226445Aluminium lithium hydride

HCID 223944381-Isopropylpiperidine-4-carboxamide

生成物 1

HCID 7258859(1-Isopropylpiperidin-4-yl)methanamine収率 76.2%

実験手順

Prepared from 1-isopropylpiperidine-4-carboxamide (2.5 g, 14.7 mmol) and LAH (1.12 g, 29.4 mmol) according to general the procedure used for Example 8 (Step B) to give 1.75 g of title compound as an oil.

出典と根拠

ORDレコード: ord-c36511e6c8364156b2229f810aea1e89
出典データセット: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06506901B2

反応ノート

読み込み中…