Benzamide, 2,6-difluoro-N-methyl- → 1-(2,6-Difluorophenyl)-N-methylmethanamine

HRID 1634809ノート

反応式

HRID 1634809 の反応式
[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[C:3]=1[C:4]([NH:6][CH3:7])=O.B.CSC>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[C:3]=1[CH2:4][NH:6][CH3:7]

参加物

4

反応物 2

HCID 4106176Benzamide, 2,6-difluoro-N-methyl-HCID 12423031(Dimethyl sulfide)trihydroboron

生成物 1

HCID 167901141-(2,6-Difluorophenyl)-N-methylmethanamine収率 51%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Prepared from 2,6-difluoro-N-methyl-benzamide (3.2 g, 18.7 mmol) and borane-methylsulfide (47 mL of a 2 M solution in toluene) according to the procedure used for example 84 (Step B) to give 1.5 g of the title compound which was used directly in the next prep.

出典と根拠

ORDレコード
ord-72b2b6556c0246ec9557aa545f1d2381
出典データセット
uspto-grants-2003_01
特許番号
US06506901B2

反応ノート

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