Potassium Carbonate → [1-({4-[amino(hydroxyimino)methyl]phenyl}sulfonyl)-4-piperidinyl]methyl-carbamic Acid t-butyl Ester

HRID 1634830ノート

反応式

HRID 1634830 の反応式
[C:1]([O:5][C:6](=[O:26])[NH:7][CH2:8][CH:9]1[CH2:14][CH2:13][N:12]([S:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=2)(=[O:17])=[O:16])[CH2:11][CH2:10]1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].Cl.[OH-:34].[NH4+:35]>C(O)C>[C:1]([O:5][C:6](=[O:26])[NH:7][CH2:8][CH:9]1[CH2:10][CH2:11][N:12]([S:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]([NH2:35])=[N:25][OH:34])=[CH:20][CH:19]=2)(=[O:17])=[O:16])[CH2:13][CH2:14]1)([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 13908798HCID 13908798、化合物HCID 70117214{1-[(4-Cyanophenyl)sulfonyl]-4-piperidinyl}methylcarbamic acid t-butyl ester

生成物 1

HCID 74062249[1-({4-[amino(hydroxyimino)methyl]phenyl}sulfonyl)-4-piperidinyl]methyl-carbamic Acid t-butyl Ester

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

{1-[(4-cyanophenyl)sulfonyl]-4-piperidinyl}methylcarbamic acid t-butyl ester (1 g, 2.6 mmol), potassium carbonate (1.8 g, 13 mmol), and ammonium hydroxide hydrochloride (0.916 g, 13 mmol) were heated in ethanol (5 ml) at reflux for 2.5 days. The reaction was cooled in an ice-water bath, and filtered. The solid was washed with cold ethanol, and evaporated to a white solid (0.870 g, 2.10 mmol).

後処理

  1. temperatureat reflux for 2.5 days
  2. temperatureThe reaction was cooled in an ice-water bath
  3. filtrationfiltered
  4. washThe solid was washed with cold ethanol

出典と根拠

ORDレコード
ord-fcb8a318b3014d3ab5a710d5f541a8fd
出典データセット
uspto-grants-2003_01
特許番号
US06506901B2

反応ノート

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