4-Hydroxymethyl-2-(3,4,5-trimethoxyphenyl)pyridine → 2-(3,4,5-Trimethoxyphenyl)pyridine-4-carboaldehyde

HRID 1634894ノート

反応式

HRID 1634894 の反応式
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=2)[CH:4]=1>C1C=CC=CC=1.[O-2].[O-2].[Mn+4]>[CH3:20][O:19][C:11]1[CH:10]=[C:9]([C:5]2[CH:4]=[C:3]([CH:2]=[O:1])[CH:8]=[CH:7][N:6]=2)[CH:14]=[C:13]([O:15][CH3:16])[C:12]=1[O:17][CH3:18]

参加物

4

反応物 1

HCID 161259364-Hydroxymethyl-2-(3,4,5-trimethoxyphenyl)pyridine

生成物 1

HCID 186750102-(3,4,5-Trimethoxyphenyl)pyridine-4-carboaldehyde

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒2 回HCID 241Benzene溶媒

実験手順

4-Hydroxymethyl-2-(3,4,5-Trimethoxyphenyl)pyridine (1.01 g) was dissolved in benzene (10 mL), and to the solution activated manganese dioxide (purity: 85%, 3.78 g) was added. The mixture was stirred at room temperature for 5 hours, and activated manganese dioxide (purity: 85%, 3.78 g) was additionally added. The mixture was stirred overnight. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=1:1) to obtain the title compound.

後処理

  1. additionwas added
  2. stirringThe mixture was stirred overnight
  3. filtrationThe reaction mixture was filtered
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customThe residue was purified by column chromatography on silica gel (hexane:ethyl acetate=1:1)

出典と根拠

ORDレコード
ord-9b766fb091704174bc69a6d4a7d607b2
出典データセット
uspto-grants-2003_01
特許番号
US06509329B1

反応ノート

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