Methanol → (4R,9aS)-4-(3,4,5-Trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one

HRID 16350ノート

反応式

HRID 16350 の反応式
CO.[F:3][C:4]1[CH:5]=[C:6]([C@@H:12]2[CH2:17][O:16][CH2:15][C@@H:14]3[CH:18]=[CH:19][CH2:20][C:21](=[O:22])[N:13]23)[CH:7]=[C:8]([F:11])[C:9]=1[F:10]>[H][H].[Pt]=O>[F:3][C:4]1[CH:5]=[C:6]([C@@H:12]2[CH2:17][O:16][CH2:15][C@@H:14]3[CH2:18][CH2:19][CH2:20][C:21](=[O:22])[N:13]23)[CH:7]=[C:8]([F:11])[C:9]=1[F:10]

参加物

5

反応物 2

HCID 887MethanolHCID 67464206(4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-one

生成物 1

HCID 44124045(4R,9aS)-4-(3,4,5-Trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one収率 100.1%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 178418361HCID 178418361、化合物溶媒

実験手順

Platinum oxide (20.1 mg) was added to a methanol solution (6 mL) of (4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-one (250 mg). The resulting reaction solution was stirred at room temperature for 2 hr in hydrogen atmosphere and then filtered through Celite. The filtrate was concentrated under reduced pressure to give 252 mg of the title compound. The physical property values of this compound were as follows:

後処理

  1. customThe resulting reaction solution
  2. filtrationfiltered through Celite
  3. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-35f06373a37f4b7c9cbccb1f649396bd
出典データセット
uspto-grants-2010_06
特許番号
US07737141B2

反応ノート

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