Br[C:2]1[CH:3]=[CH:4][C:5]([O:19][CH3:20])=[C:6]([CH:8]2[C:13](=[O:14])[NH:12][C:11]3[CH:15]=[CH:16][CH:17]=[CH:18][C:10]=3[O:9]2)[CH:7]=1.[Cu][C:22]#[N:23].C(Cl)Cl.[OH-].[NH4+]>CN(C=O)C>[CH3:20][O:19][C:5]1[CH:4]=[CH:3][C:2]([C:22]#[N:23])=[CH:7][C:6]=1[CH:8]1[C:13](=[O:14])[NH:12][C:11]2[CH:15]=[CH:16][CH:17]=[CH:18][C:10]=2[O:9]1To a solution of 2-(5-bromo-2-methoxyphenyl)-2H-1,4-benzoxazin-3(4H)-one (I11) (0.90 g, 2.70 mmoles) in DMF (10 mL) was added copper (I) cyanide (1.3 g, 5 equiv.) and the mixture heated at 160° C. for 12 hours. The mixture was cooled and methylene chloride (100 mL) and aqueous ammonium hydroxide (10 mL) were added. The methylene chloride layer was separated and dried over MgSO4 which afforded the required product (I12) (0.67 g, 89%) upon evaporation in vacuo.
読み込み中…
