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Aldoxime → 3-[3-(3-Methyl-isoxazol-5-yl)-phenyl)-3-oxo-propionic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aldoxime | HCID 7863 | — |
| 反応物 | Chlorosuccinimide | HCID 31398 | — |
| 反応物 | Ethyl 3-ethynylbenzoate | HCID 15540684 | — |
| 反応物 | Ethyl 3-(3-methyl-isoxazol-5-yl)-benzoate | HCID 22224947 | — |
| 反応物 | Lithium Tert-butyl Acetate | HCID 86586795 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 3-[3-(3-Methyl-isoxazol-5-yl)-phenyl)-3-oxo-propionic acid tert-butyl ester | HCID 69592871 | — |
反応手順
Prepared from ethyl 3-(3-methyl-isoxazol-5-yl)-benzoate [prepared by reaction of ethyl 3-ethynylbenzoate [CAS-No. 178742-95-5] with a mixture of NCS, acetaldoxime, Et3N and cat. amount of pyridine in CHCl3 at 50° C. according to Tetrahedron 1984, 40, 2985-2988] by treatment with lithium tert.-butyl acetate according to general procedure H (method b). Obtained as a yellow solid (2.54 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06509328B1 |
| 出典データセット | uspto-grants-2003_01 |
| ORD ID | ord-ea3c289a8f1d4ca7bea839468e22e0a1 |
| 出典メモ | uspto-grants-2003_01 |