Methyl 4-(2-oxopyrrolidin-1-yl)benzoate → 1-(4-Methoxycarbonyl-2-nitrophenyl)pyrrolidin-2-one

HRID 1635552ノート

反応式

HRID 1635552 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])=[CH:7][CH:6]=1)=[O:4].F[B-](F)(F)F.[O:22]=[N+:23]=[O:24]>ClCCl>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])=[C:9]([N+:23]([O-:24])=[O:22])[CH:10]=1)=[O:4]

参加物

4

反応物 2

HCID 757827Methyl 4-(2-oxopyrrolidin-1-yl)benzoateHCID 11073463Nitronium tetrafluoroborate

生成物 1

HCID 106830071-(4-Methoxycarbonyl-2-nitrophenyl)pyrrolidin-2-one収率 92%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
10 °C

実験手順

An ice-cold mixture of the above ester (2.0 g, 9.1 mmol) in 30 mL of dichloromethane was treated with nitronium tetrafluoroborate (2.5 g, 18.8 mmol). The resulting mixture was stirred at 10° C. for 2 h and then at ambient temperature for 4 h. The reaction mixture was quenched with water (20 mL) and the organic layer was evaporated under vacuum. The white solid precipitate was collected by filtration, washed with water and dried to give 2.2 g (92%) of 1-(4-methoxycarbonyl-2-nitrophenyl)pyrrolidin-2-one, mp 159-161° C. (chloroforn/ether).

後処理

  1. waitat ambient temperature for 4 h
  2. customThe reaction mixture was quenched with water (20 mL)
  3. customthe organic layer was evaporated under vacuum
  4. filtrationThe white solid precipitate was collected by filtration
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-9ec9cb610b734f5b982a2c9f3c33e673
出典データセット
uspto-grants-2003_01
特許番号
US06509359B1

反応ノート

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