関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Nefazodone | HCID 4449 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Nefazodone Hydrochloride | HCID 54911 | — |
反応手順
Nefazodone HCl was prepared in accordance with Example 2 of U.S. Pat. No. 4,338,317. Nefazodone HCI was dissolved in water with gentle heating (40-45° C.). An equimolar quantity of sodium hydroxide solution (0.1 N) was added with constant stirring while cooling with ice. Nefazodone base precipitated as a sticky gum which was separated and washed repeatedly with water. The base was washed with water until no chloride ions (AgNO3 test) were detected in the washings. Nefazodone base was then dissolved and crystallized from isopropyl alcohol (IPA) to give a solid melting 81-83° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06034085 |
|---|
| 出典データセット | uspto-grants-2000_03 |
|---|
| ORD ID | ord-02174f92564844058b99dde18f2e5844 |
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| 出典メモ | uspto-grants-2000_03 |
|---|
