3-Pyridinecarboxaldehyde → 4-(Pyridin-3-ylmethyleneamino)-5-methyl-1,2,4-triazol-3-one
反応式
[NH2:1][N:2]1[C:6]([CH3:7])=[N:5][NH:4][C:3]1=[O:8].[N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]=O)[CH:10]=1>Cl>[N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]=[N:1][N:2]2[C:6]([CH3:7])=[N:5][NH:4][C:3]2=[O:8])[CH:10]=1参加物
4
実験手順
A mixture of 5.7 g of 4-amino-5-methyl-1,2,4-triazol-3-one and 100 ml of alcohol is heated to the reflux temperature and 5.4 g of pyridine-3-carbaldehyde and 2 drops of 6N hydrochloric acid are added thereto. After 14 hours under reflux the reaction mixture is cooled to 20°. The product that has precipitated is then filtered off with suction and dried under a high vacuum. 3.4 g of the title compound having a melting point of 208-210° are obtained.
後処理
- additionare added
- temperatureAfter 14 hours under reflux the reaction mixture
- temperatureis cooled to 20°
- customThe product that has precipitated
- filtrationis then filtered off with suction
- customdried under a high vacuum
- customare obtained
出典と根拠
- ORDレコード
- ord-8b533e8af45d423eba96da450befe016
- 出典データセット
- uspto-grants-2000_03
- 特許番号
- US06034083
反応ノート
読み込み中…