Methyl carbazate → N'-[2-(5-Methoxy-2-oxo-[1,3,4]thiadiazol-3-yl)-1-methyl-ethylidene]-hydrazinecarboxylic acid methyl ester

HRID 1636321ノート

反応式

HRID 1636321 の反応式
[C:1]([O:5][CH3:6])(=[O:4])[NH:2][NH2:3].[CH3:7][O:8][C:9]1[S:13][C:12](=[O:14])[N:11]([CH2:15][C:16](=O)[CH3:17])[N:10]=1>CO>[CH3:6][O:5][C:1]([NH:2][N:3]=[C:16]([CH3:17])[CH2:15][N:11]1[N:10]=[C:9]([O:8][CH3:7])[S:13][C:12]1=[O:14])=[O:4]

参加物

4

反応物 2

HCID 80519Methyl carbazateHCID 193507245-Methoxy-3-(2-oxopropyl)-3H-[1,3,4]thiadiazol-2-one

生成物 1

HCID 53777430N'-[2-(5-Methoxy-2-oxo-[1,3,4]thiadiazol-3-yl)-1-methyl-ethylidene]-hydrazinecarboxylic acid methyl ester収率 78.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

9.1 g of methyl carbazate are added to a solution of 18.8 g of 5-methoxy-3-(2-oxo-propyl)-3H-[1,3,4]thiadiazol-2-one (Comp. 7.001) in 150 ml of methanol and the mixture is then stirred at room temperature for 36 hours. The reaction mixture is concentrated by evaporation and the residue is stirred with isopropanol and filtered with suction to yield 20.5 g of crystals of the title compound having a melting point of 142-143°.

後処理

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. stirringthe residue is stirred with isopropanol
  3. filtrationfiltered with suction

出典と根拠

ORDレコード
ord-9df8c800a475489eb424b4b5501d52a7
出典データセット
uspto-grants-2000_03
特許番号
US06034083

反応ノート

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