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Iodine chloride → 2-(4'-Amino-3'-iodophenyl)-6-methoxybenzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodine chloride | HCID 24640 | — |
| 反応物 | 4-(6-Methoxy-1,3-benzothiazol-2-yl)aniline | HCID 391870 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-(4'-Amino-3'-iodophenyl)-6-methoxybenzothiazole | HCID 10068437 | 56.1% |
反応手順
2-(4'-Aminophenyl)-6-methoxybenzothiazole (0.22 g, 0.84 mmol) was treated with iodine monochloride (0.21 g, 1.3 mmol) in acetic acid according to the above-described general procedure for iodination. Crude product was purified by flash chromatography on silica gel, using ethyl acetate-hexane (1:3) as eluent, to give brown small crystals (0.18 g, 54.9%), m.p. 179.2-181.1° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06034246 |
| 出典データセット | uspto-grants-2000_03 |
| ORD ID | ord-06fc31bab1024d1a891d176b03be7e52 |
| 出典メモ | uspto-grants-2000_03 |