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Benzenamine, 4-(2-benzothiazolyl)-2-iodo- → 2-(4-Amino-3-cyanophenyl)benzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzenamine, 4-(2-benzothiazolyl)-2-iodo- | HCID 384526 | — |
| 反応物 | 4-(2-Benzothiazolyl)-2-chloro-benzenamine | HCID 387950 | — |
| 反応物 | HCID 178418546 | HCID 178418546 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(4-Amino-3-cyanophenyl)benzothiazole | HCID 10514897 | — |
反応手順
2-(4'-amino-3'-iodophenyl)benzothiazole (0.123 g, 0.35 mmol) was treated with copper (I) cyanide (63 mg, 0.7 mmol) in DMF according to procedure for preparation of 2-(4'-amino-3'-chlorophenyl) benzothiazole. The crude product was purified by chromatography on silica gel, eluting with ethyl acetate-hexane (2:3) to give a pale yellow powder (0.032 g, 36%%), m.p. 207.3-211.0° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06034246 |
| 出典データセット | uspto-grants-2000_03 |
| ORD ID | ord-fb8d2ea72f0449f08345ff284ecb9fdf |
| 出典メモ | uspto-grants-2000_03 |