Hydrochloric Acid → 5-Amino-2-phenyl-1,3,4,5-tetrahydrobenz[cd]indole hydrochloride

HRID 1637282ノート

反応式

HRID 1637282 の反応式
[NH2:1][CH:2]1[C:12]2[C:13]3[C:5](=[C:6]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[NH:7][C:8]=3[CH:9]=[CH:10][CH:11]=2)[CH2:4][CH2:3]1.[ClH:20]>C(O)C>[ClH:20].[NH2:1][CH:2]1[C:12]2[C:13]3[C:5](=[C:6]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[NH:7][C:8]=3[CH:9]=[CH:10][CH:11]=2)[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 101988185-Amino-2-phenyl-1,3,4,5-tetrahydrobenz[cd]indole

生成物 1

HCID 193483565-Amino-2-phenyl-1,3,4,5-tetrahydrobenz[cd]indole hydrochloride収率 76%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

A portion (1.0 g) of the compound obtained in Example 81 was suspended in ethanol (10 ml) and to the suspension was added a solution (2.5 ml) of 20% hydrochloric acid in ethanol. The mixture was stirred for 10 minutes at room temperature. The reaction mixture was concentrated under reduced pressure. The crystals obtained were washed with ether and ether/methanol to yield 0.87 g (76%) of the titled compound as pale brown crystals.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customThe crystals obtained
  3. washwere washed with ether and ether/methanol

出典と根拠

ORDレコード
ord-d6fba87e077448f9ad96bfde303fbda8
出典データセット
uspto-grants-2000_03
特許番号
US06040331

反応ノート

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