N-(2-t-butyl-5-methoxycarbonylphenyl)-3-(4-formyl-2-methoxyphenyl)octanamide → N-(2-t-Butyl-5-carboxyphenyl)-3-(2-methoxy-4-propionylphenyl)octanamide

HRID 1637546ノート

反応式

HRID 1637546 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([O:13]C)=[O:12])=[CH:7][C:6]=1[NH:15][C:16](=[O:34])[CH2:17][CH:18]([C:24]1[CH:29]=[CH:28][C:27]([CH:30]=[O:31])=[CH:26][C:25]=1[O:32][CH3:33])[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])([CH3:4])([CH3:3])[CH3:2].[CH2:35]([Mg]Br)[CH3:36]>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([OH:13])=[O:12])=[CH:7][C:6]=1[NH:15][C:16](=[O:34])[CH2:17][CH:18]([C:24]1[CH:29]=[CH:28][C:27]([C:30](=[O:31])[CH2:35][CH3:36])=[CH:26][C:25]=1[O:32][CH3:33])[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])([CH3:3])([CH3:4])[CH3:2]

参加物

3

反応物 2

HCID 19348464N-(2-t-butyl-5-methoxycarbonylphenyl)-3-(4-formyl-2-methoxyphenyl)octanamideHCID 178418443HCID 178418443、化合物

生成物 1

HCID 19348559N-(2-t-Butyl-5-carboxyphenyl)-3-(2-methoxy-4-propionylphenyl)octanamide

実験手順

Following a similar procedure to that described in Preparation 64A(i), but using N-(2-t-butyl-5-methoxycarbonylphenyl)-3-(4-formyl-2-methoxyphenyl)octanamide (prepared as described in Preparation 63A) and ethylmagnesium bromide, the title compound was obtained as a foam-like substance.

後処理

  1. customthat described in Preparation 64A(i)

出典と根拠

ORDレコード
ord-c944e6d42dd045cb95d17f0a3cfc249e
出典データセット
uspto-grants-2000_03
特許番号
US06040339

反応ノート

読み込み中…