Potassium Hydroxide → 3-(5-cyano-1H-indol-3-yl)propanoic Acid

HRID 1637705ノート

反応式

HRID 1637705 の反応式
C[O:2][C:3](=[O:17])[CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15]#[N:16])[CH:13]=2)[NH:8][CH:7]=1.[OH-].[K+]>CO>[C:15]([C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:5][CH2:4][C:3]([OH:17])=[O:2])#[N:16]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 19921624methyl 3-(5-cyano-1H-indol-3-yl)propanoate

生成物 1

HCID 104432213-(5-cyano-1H-indol-3-yl)propanoic Acid収率 100.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methy-5-cyanoindole-3-propionate (200 mg) was saponified in MeOH (10 mL)/KOH (150 mg, 0.88 mmol) at rt for 18 h. The solution was concentrated in vacuo, dissolved in water and washed with chloroform. The acidic layer was acidified and extracted with ethyl acetate, dried with Na2SO4, filtered and concentrated in vacuo to afford 188 mg of product. 1H NMR (CD3OD) δppm 2.83 (t, 2H, J=6.6Hz), 4.43 (t, 2H, J=6.6 Hz), 6.6 (nd,1H, J3.2 Hz), 7.42 (d, 2H, J=7.3 Hz), 7.43 (s, 1H), 7.61 (d, 1H, J=7.3 Hz), 7.99 (s, 1H); LRMS ESI (M+H)+ 215.

後処理

  1. customat rt
  2. customfor 18 h
  3. concentrationThe solution was concentrated in vacuo
  4. dissolutiondissolved in water
  5. washwashed with chloroform
  6. extractionextracted with ethyl acetate
  7. dry with materialdried with Na2SO4
  8. filtrationfiltered
  9. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-5836881b437f4117a26e204c2de749bc
出典データセット
uspto-grants-2000_03
特許番号
US06043257

反応ノート

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