Ethanol → HCID 54527564、化合物

HRID 1637933ノート

反応式

HRID 1637933 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][CH:17]=1)[CH:7]=[C:8]1[NH:12][C:11](=[O:13])[NH:10][C:9]1=[O:14])([O-])=O.NC1SC=C(C2C=CC(N)=CC=2)N=1.CCO>CN(C=O)C.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][CH:17]=1)[CH:7]=[C:8]1[NH:12][C:11](=[O:13])[NH:10][C:9]1=[O:14]

参加物

6

反応物 3

HCID 702EthanolHCID 3778255-(3-nitrobenzylidene)imidazolidine-2,4-dioneHCID 6055642-Amino-4-(4-aminophenyl)thiazole

生成物 1

HCID 54527564HCID 54527564、化合物

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 6228Dimethylformamide溶媒

実験手順

2.3 g (10 mmol) of crude 3-nitro-benzylidene-hydantoin, melting point 280-284° C., (prepared as described in Example 6 in (a)) are hydrogenated in 60 ml of DMF and 40 ml EtOH on 2 g of Raney nickel for 36 hours at 20° C. and 3.5 bar. It is filtered over kieselguhr and the filtrate is evaporated down in vacuo. The evaporation residue is crystallised with ether.

後処理

  1. filtrationIt is filtered over kieselguhr
  2. customthe filtrate is evaporated down in vacuo
  3. customThe evaporation residue is crystallised with ether

出典と根拠

ORDレコード
ord-868b03d787424b74b9f08e5b99c7e1e2
出典データセット
uspto-grants-2000_03
特許番号
US06043254

反応ノート

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