Hydrochloric Acid → 2-(3-Hydroxy-2-pyridyl)-4-thiazolecarboxylic acid

HRID 1638315ノート

反応式

HRID 1638315 の反応式
[OH:1][C:2]1[C:3]([C:8]2[S:9][CH:10]=[C:11]([C:13]([O:15]CC)=[O:14])[N:12]=2)=[N:4][CH:5]=[CH:6][CH:7]=1.[OH-].[K+].Cl>C(O)C.O>[OH:1][C:2]1[C:3]([C:8]2[S:9][CH:10]=[C:11]([C:13]([OH:15])=[O:14])[N:12]=2)=[N:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 135967484Ethyl 2-(3-hydroxy-2-pyridyl)-4-thiazolecarboxylate

生成物 1

HCID 1362052682-(3-Hydroxy-2-pyridyl)-4-thiazolecarboxylic acid収率 92.4%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a solution of ethyl 2-(3-hydroxy-2-pyridyl)-4-thiazolecarboxylate (350 mg) dissolved in ethanol (7 ml) at 80° C. was added a solution of potassium hydroxide (436 mg) in water (5.5 ml) and the mixture was allowed to react at the same condition for 30 minutes. Then the reaction mixture was nuetralized with 1N--HCl under ice-cooling. The resulting solids were sucked off and dried to give yellowish crystals of 2-(3-hydroxy-2-pyridyl)-4-thiazolecarboxylic acid (287 mg, 92%), m.p. above 300° C.

後処理

  1. customto react at the same condition for 30 minutes
  2. customdried

出典と根拠

ORDレコード
ord-fa714af956674eee80af1b01bc30c5d6
出典データセット
uspto-grants-1989_11
特許番号
US04879295

反応ノート

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