Ethyl bromopyruvate → HCID 19842281、化合物
反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[S:8])[NH2:7].Br[CH2:10][C:11](=O)[C:12]([O:14][CH2:15][CH3:16])=[O:13]>C(O)C>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[S:8][CH:10]=[C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:7]=1参加物
4
実験手順
To a solution of 2-furan-thiocarboxamide (1.63 g) dissolved in dry ethanol (65 ml) with heating was added ethyl bromopyruvate (1.97 ml) and the mixture was refluxed for 30 minutes. Then the solvent was removed from the reaction mixture, and the residue was treated with water, neutralized with 4% aqueous sodium carbonate and extracted three times with ethyl acetate. The organic layer was washed with saturated aqueous NaCl, dried (anhydrous Na2SO4) and concentrated to give yellowish crystals of ethyl 2-(2-furyl)-4-thiazolecarboxylate (3.12 g).
後処理
- temperaturewith heating
- temperaturethe mixture was refluxed for 30 minutes
- customThen the solvent was removed from the reaction mixture
- additionthe residue was treated with water
- extractionextracted three times with ethyl acetate
- washThe organic layer was washed with saturated aqueous NaCl
- dry with materialdried (anhydrous Na2SO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-0192acb3e34d4d51889bafa6a63cac9f
- 出典データセット
- uspto-grants-1989_11
- 特許番号
- US04879295
反応ノート
読み込み中…