Styrene Oxide → 2-Allylamino-1-phenyl-ethanol

HRID 1639157ノート

反応式

HRID 1639157 の反応式
[CH2:1]1[O:9][CH:2]1[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:10]([NH2:13])[CH:11]=[CH2:12]>>[CH2:10]([NH:13][CH2:1][CH:2]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[OH:9])[CH:11]=[CH2:12]

参加物

3

反応物 2

HCID 7276Styrene OxideHCID 7853Allylamine

生成物 1

HCID 2925542-Allylamino-1-phenyl-ethanol

実験手順

A mixture of styrene oxide (24 mL, 0.2 moles) and allylamine (60.8 mL, 0.8 moles) was heated to reflux under nitrogen atmosphere, for 24 hours. Upon cooling, product crystallized and was triturated with hexane. Recrystallization from hexane afforded the title compound essentially uncontaminated by the other possible regioisomer. Ms m+/z=177; H1NMR (CDCl3): δ 7.3 (br.s, 5H), 5.6-6.1 (m, 1H), 4.9-5.4 (m, 2H), 4.75 (m, 1H), 3.2 (br.d, 2H), 2.9 (br.s, 2H), 2.7 (m, 2H).

後処理

  1. temperaturewas heated
  2. temperatureto reflux under nitrogen atmosphere, for 24 hours
  3. temperatureUpon cooling
  4. customproduct crystallized
  5. customwas triturated with hexane
  6. customRecrystallization from hexane

出典と根拠

ORDレコード
ord-cc843f7929f04dc0a82af1ef5073e075
出典データセット
uspto-grants-1989_11
特許番号
US04882429

反応ノート

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