関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-bromo-N-(4-bromo-2-fluorobenzyl)-2-nitrobenzamide | HCID 14458987 | — |
| 触媒 | Iron | HCID 23925 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide | HCID 14458995 | 98% |
反応手順
A mixture of 4-bromo-N-(4-bromo-2-fluorobenzyl)-2-nitrobenzamide (3.4 g) and iron (1.45 g) in acetic acid (66 ml) was stirred at 100° C. for 30 minutes. After cooling, iron was filtered off. The filtrate was evaporated to give a residue, which was made alkaline with aqueous 1N sodium hydroxide and extracted with ethyl acetate. The extract was washed with water and dried. Removal of the solvent gave 2-amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide (3.10 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04883800 |
|---|
| 出典データセット | uspto-grants-1989_11 |
|---|
| ORD ID | ord-4eea3f8d26614eabaecd02eb0fccda4f |
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| 出典メモ | uspto-grants-1989_11 |
|---|
