Aniline → 7-Cyano-2-(3-methyl[1,2,4]thiadiazol-5-yl)heptanoic acid phenylamide

HRID 1639574ノート

反応式

HRID 1639574 の反応式
F[P-](F)(F)(F)(F)F.[N:8]1(OC(N(C)C)=[N+](C)C)[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2N=N1.NC1C=CC=CC=1.[C:32]([CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH:39]([C:43]1[S:47][N:46]=[C:45]([CH3:48])[N:44]=1)[C:40](O)=[O:41])#[N:33].C(N(CC)CC)C>ClCCl>[C:12]1([NH:8][C:40](=[O:41])[CH:39]([C:43]2[S:47][N:46]=[C:45]([CH3:48])[N:44]=2)[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34][C:32]#[N:33])[CH:11]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

6

反応物 4

HCID 6115AnilineHCID 8471TriethylamineHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 593780557-Cyano-2-(3-methyl[1,2,4]thiadiazol-5-yl)heptanoic acid

生成物 1

HCID 593780587-Cyano-2-(3-methyl[1,2,4]thiadiazol-5-yl)heptanoic acid phenylamide収率 73%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred mixture of O-(1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (0.63 g, 1.64 mmol) and aniline (0.14 g, 1.5 mmol) in dichloromethane (10 mL) was added over 5 min the crude solution of 7-cyano-2-(3-methyl[1,2,4]thiadiazol-5-yl)heptanoic acid (2021052) and triethylamine. The resultant reaction mixture was then stirred at room temperature overnight before being quenched with citric acid (5 g) in water (50 mL) and extracted with dichloromethane (3×50 mL). The combined organic fractions were dried (MgSO4) and the solvent was removed under reduced pressure. The crude product was purified by flash chromatography (3:1 hexane/ethyl acetate followed by 1:1 hexane/ethyl acetate) to afford 7-cyano-2-(3-methyl[1,2,4]thiadiazol-5-yl)heptanoic acid phenylamide (2021044) (440 mg, 73% over two steps) as a yellow oil.

後処理

  1. customThe resultant reaction mixture
  2. custombefore being quenched with citric acid (5 g) in water (50 mL)
  3. extractionextracted with dichloromethane (3×50 mL)
  4. dry with materialThe combined organic fractions were dried (MgSO4)
  5. customthe solvent was removed under reduced pressure
  6. customThe crude product was purified by flash chromatography (3:1 hexane/ethyl acetate followed by 1:1 hexane/ethyl acetate)

出典と根拠

ORDレコード
ord-d25733321a6941cf8a02b8219497eeca
出典データセット
uspto-grants-2012_02
特許番号
US08110577B2

反応ノート

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