Acetohydroxamic Acid → 4-Methoxy-1,2-benzoxazol-3-amine

HRID 16396ノート

反応式

HRID 16396 の反応式
[C:1]([NH:4][OH:5])(=O)[CH3:2].CC(C)([O-])C.[K+].F[C:13]1[CH:20]=[CH:19]C=[C:17]([O:21][CH3:22])[C:14]=1C#N.[Cl-].[Na+].C[N:26](C)C=O>>[CH3:22][O:21][C:17]1[C:2]2[C:1]([NH2:26])=[N:4][O:5][C:19]=2[CH:20]=[CH:13][CH:14]=1

参加物

6

反応物 5

HCID 1990Acetohydroxamic AcidHCID 5234Sodium ChlorideHCID 6228DimethylformamideHCID 5231012-Fluoro-6-methoxybenzonitrileHCID 23665647Potassium tert-butoxide

生成物 1

HCID 27797514-Methoxy-1,2-benzoxazol-3-amine

反応条件

温度
60 °C

実験手順

709.5 mg (9.45 mmol) of acetohydroxamic acid are initially charged in 8 ml of anhydrous dimethylformamide, and 1.06 g (9.45 mmol) of potassium tert-butoxide are added at room temperature. After 40 minutes of stirring, 1 g (6.62 mmol) of 2-fluoro-6-methoxybenzonitrile is added. The mixture is heated at 60° C. for 16 hours. 20 ml of saturated sodium chloride solution are then added to the reaction mixture. The precipitated crystals are filtered off with suction and washed with water.

後処理

  1. filtrationThe precipitated crystals are filtered off with suction
  2. washwashed with water

出典と根拠

ORDレコード
ord-acb4e7ee3dec4c4ea677ed50342c344e
出典データセット
uspto-grants-2010_06
特許番号
US07737153B2

反応ノート

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