関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-(2-methyl-2H-indazol-4-yl)prop-2-yn-1-ol | HCID 59334645 | — |
| 触媒 | Palladium on calcium carbonate | HCID 17803853 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (2Z)-3-(2-methyl-2H-indazol-4-yl)prop-2-en-1-ol | HCID 59334468 | 82.2% |
反応手順
Under hydrogen gas atmosphere, a mixture of 3-(2-methyl-2H-indazol-4-yl)prop-2-yn-1-ol (50.0 mg, 0.269 mmol) and 5% palladium-calcium carbonate (lead poisoned, Lindlar catalyst, 5 mg) in methanol (3 mL) was stirred at −10° C. for 90 min, and filtered. The solvent was evaporated under reduced pressure. The residue was washed with diisopropyl ether to give the title compound (41.6 mg, yield 82%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08110585B2 |
|---|
| 出典データセット | uspto-grants-2012_02 |
|---|
| ORD ID | ord-021d794e88834ceeb678342fd71f35ed |
|---|
| 出典メモ | uspto-grants-2012_02 |
|---|
