3-(2-methyl-2H-indazol-4-yl)prop-2-yn-1-ol → (2Z)-3-(2-methyl-2H-indazol-4-yl)prop-2-en-1-ol

HRID 1639765

反応式

HRID 1639765 の反応式
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[C:8]2[C:11]#[C:12][CH2:13][OH:14])=[N:3]1>CO.C(=O)([O-])[O-].[Ca+2].[Pd+2].C(=O)([O-])[O-]>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[C:8]2/[CH:11]=[CH:12]\[CH2:13][OH:14])=[N:3]1

参加物

4

反応物 1

HCID 593346453-(2-methyl-2H-indazol-4-yl)prop-2-yn-1-ol

生成物 1

HCID 59334468(2Z)-3-(2-methyl-2H-indazol-4-yl)prop-2-en-1-ol収率 82.2%

試薬・触媒・溶媒 2

HCID 17803853Palladium on calcium carbonate触媒HCID 887Methanol溶媒

反応条件

温度
-10 °C

実験手順

Under hydrogen gas atmosphere, a mixture of 3-(2-methyl-2H-indazol-4-yl)prop-2-yn-1-ol (50.0 mg, 0.269 mmol) and 5% palladium-calcium carbonate (lead poisoned, Lindlar catalyst, 5 mg) in methanol (3 mL) was stirred at −10° C. for 90 min, and filtered. The solvent was evaporated under reduced pressure. The residue was washed with diisopropyl ether to give the title compound (41.6 mg, yield 82%).

後処理

  1. filtrationfiltered
  2. customThe solvent was evaporated under reduced pressure
  3. washThe residue was washed with diisopropyl ether

出典と根拠

ORDレコード
ord-021d794e88834ceeb678342fd71f35ed
出典データセット
uspto-grants-2012_02
特許番号
US08110585B2

関連ノート

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